FMOC-4-PHENYL-PIPERIDINE-4-CARBOXYLIC ACID

FMOC-4-PHENYL-PIPERIDINE-4-CARBOXYLIC ACID - Names and Identifiers

Name	1-[(9H-fluoren-9-ylmethoxy)carbonyl]-4-phenylpiperidine-4-carboxylic acid
Synonyms	RARECHEM EM WB 0183 FMOC-4-PHENYL-ISONIPECOTIC ACID FMOC-4-PHENYL-4-PIPERIDINECARBOXYLIC ACID FMOC-4-PHENYL-PIPIRIDINE-4-CARBOXYLIC ACID FMOC-4-PHENYL-PIPERIDINE-4-CARBOXYLIC ACID 1-[(9H-fluoren-9-ylmethoxy)carbonyl]-4-phenylpiperidine-4-carboxylic acid 1-(((9H-fluoren-9-yl)methoxy)carbonyl)-4-phenylpiperidine-4-carboxylic acid
CAS	215190-19-5
InChI	InChI=1/C27H25NO4/c29-25(30)27(19-8-2-1-3-9-19)14-16-28(17-15-27)26(31)32-18-24-22-12-6-4-10-20(22)21-11-5-7-13-23(21)24/h1-13,24H,14-18H2,(H,29,30)

FMOC-4-PHENYL-PIPERIDINE-4-CARBOXYLIC ACID - Physico-chemical Properties

Molecular Formula	C27H25NO4
Molar Mass	427.49
Density	1.278g/cm³
Boling Point	633.8°C at 760 mmHg
Flash Point	337.1°C
Vapor Presure	6.2E-17mmHg at 25°C
Storage Condition	2-8°C
Refractive Index	1.635

FMOC-4-PHENYL-PIPERIDINE-4-CARBOXYLIC ACID - Risk and Safety

WGK Germany	3
FLUKA BRAND F CODES	10
HS Code	29333990
Hazard Class	IRRITANT

FMOC-4-PHENYL-PIPERIDINE-4-CARBOXYLIC ACID - Introduction

1-[(9H-fluoren-9-ylmethoxy)]-carbonic acid, also known as 1-[(9H-fluoren-9-ylmethoxy)carbonyl]-4-phenylpiperidine-4-carboxylic acid, it is an organic compound. The following is an introduction to its nature, use, preparation and safety information:

Nature:
-Appearance: White or slightly yellow crystalline powder
-molecular formula: C28H23NO4
-Molecular weight: 441.49g/mol
-Melting point: 183-188 ° C
-Solubility: Soluble in organic solvents such as methylene chloride, dimethyl sulfite and methanol

Use:
- 1-[(9H-fluoren-9-ylmethoxy)-benzol is a commonly used reagent to construct acid, which is commonly used in solid-phase synthesis of piperidine skeleton.
-It can be used for the synthesis of peptides, proteins and other small organic compounds.
-In solid phase synthesis, it can be used as a protecting group (Fmoc protecting group) to generate active amino acids or peptide fragments through reaction.

Method:
The preparation of 1-[(9H-fluoren-9-ylmethoxy)]-carbonyl can be carried out by the following steps:
1. Dissolve 4-phenylpiperidine in dimethylsulfite.
2. Suspend fluorenecyl chloride in the above solution at low temperature.
3. Slowly add sodium bicarbonate solution under alkaline conditions.
4. After formation of precipitate, filter and wash.
5. The target product 1-[(9H-fluoren-9-ylmethoxy)carbonyl]-fluoryl acid can be obtained after the obtained product is properly Crystal treated.

Safety Information:
- 1-[(9H-fluoren-9-ylmethoxy)]-carbonyl is generally stable and harmless under normal use and storage conditions.
-However, as a chemical, it is still necessary to pay attention to safe operation when handling and using.
-Contact with strong oxidants and high temperature conditions must be avoided.
-Appropriate protective measures, such as laboratory gloves and goggles, should be worn.
-When storing, keep dry, avoid sun exposure, and keep away from flammable and explosive materials.

Last Update：2024-04-10 22:29:15